Synaptic background activity influences spatiotemporal integration in single pyramidal cells.
نویسندگان
چکیده
منابع مشابه
Synaptic background activity a!ects the dynamics of dendritic integration in model neocortical pyramidal neurons
Neocortical pyramidal neurons in vivo are subject to an intense synaptic background activity which may signi"cantly impact on dendritic integration, but this aspect is largely unexplored. Here we use computational models of morphologically-reconstructed pyramidal neurons, in which synaptic background activity was simulated according to recent measurements in cat parietal cortex. We show that ba...
متن کاملSynaptic background activity affects the dynamics of dendritic integration in model neocortical pyramidal neurons
Neocortical pyramidal neurons in vivo are subject to an intense synaptic background activity which may signi"cantly impact on dendritic integration, but this aspect is largely unexplored. Here we use computational models of morphologically-reconstructed pyramidal neurons, in which synaptic background activity was simulated according to recent measurements in cat parietal cortex. We show that ba...
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Cortical pyramidal neurons receive thousands of synaptic inputs arriving at different dendritic locations with varying degrees of temporal synchrony. It is not known if different locations along single cortical dendrites integrate excitatory inputs in different ways. Here we have used two-photon glutamate uncaging and compartmental modeling to reveal a gradient of nonlinear synaptic integration...
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Neocortical pyramidal neurons in vivo are subject to an intense synaptic background activity but little is known of how this activity affects cellular responsiveness and what function it may serve. These issues were examined in morphologically reconstructed neocortical pyramidal neurons in which synaptic background activity was simulated based on recent measurements in cat parietal cortex. We s...
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Despite their electrotonic compactness, neocortical pyramidal cells cannot be considered as point neurons because of nonlinear interactions between-inputs on the same dendritic branch. Using compartmental simulations. we have shown that dendritic saturation is significant for physiological levels of synaptic activation. We also show that the firing of about 10% of the total number of inhibitory...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1991
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.88.24.11569